Mary E. Klotman, MD, is professor and chair of the Department of Medicine at Duke University School of Medicine. She earned her undergraduate (zoology) and medical degrees from Duke, and then completed her internal medicine residency and a fellowship in Infectious Diseases in the Department of Medicine at Duke. She also served as assistant professor of medicine at Duke before moving to the National Institutes of Health, where she was a member of the Public Health Service and trained and worked in the Laboratory of Tumor Cell Biology under the direction of Robert C. Gallo, MD.
In 1994, Klotman joined the faculty at Mount Sinai School of Medicine in New York City, where she was a tenured professor of medicine and microbiology and associate professor of gene and cell medicine; she held the Irene and Dr. Arthur M. Fishberg Chair in Infectious Diseases. She also served as chief of the Division of Infectious Diseases for 13 years and as co-director of Mount Sinai’s Global Health and Emerging Pathogens Institute, a program designed to translate basic science discoveries into clinical therapeutics for newly emerging and re-emerging infectious diseases.
An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection. Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, and, most recently, to develop topical microbicides that could be used to block sexual transmission of HIV. She has mentored a number of pre- and post-doctoral students in laboratory-based research in infectious diseases.